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Sorry, the application deadline for this position was 9/21/2020

Reference Number: 000001368
Posted Date: 8/31/2020
Closing Date: 9/21/2020

Department: LTRI - Anesthesia
Position: Post-Doctoral Fellow

POSITION TITLE  Post-Doctoral Fellow
EMPLOYMENT TYPE  Temporary Full Time
HOURS OF WORK  37.5 hours per week
REPORTS TO  Principal Investigator

The Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, a University of Toronto affiliated research centre, is one of the world's leading centres in biomedical research.  With ground-breaking discoveries in research areas such as diabetes, genetic disorders, cancer and women’s and infants’ health, the Institute is committed to excellence in health research and the training of young investigators.  Strong partnerships with the clinical programs of Mount Sinai Hospital ensure that scientific knowledge is used to promote human health.  Your significant contributions will assist in maintaining our momentum in advancing our research.


Applications are invited for the position of first year postdoctoral fellow at the LTRI and Sinai Health System. The successful candidate will join the group led by Dr. Mrinalini Balki in the field of Obstetric Anesthesia that is committed to improving the efficacy and safety of women’s health during labor and delivery. The initial projects will mainly focus on translational laboratory studies on physiological model of human myometrium and vasculature. Our objective is to better understand the physiological, pharmacological, biomolecular and genetic mechanisms of postpartum uterine atony and bleeding, and also to facilitate discovery of selective therapies with the ultimate goal of improving patient outcomes. We will also be exploring the placental transfer of various drugs affecting neonatal outcomes, as well as effects of various vasopressors on myometrium and umbilical/uterine vasculature, with the ultimate goal of determining which vasopressor is most appropriate for the management of hypotension at cesarean delivery and for the prevention of fetal acidosis. We will continue to expand our research to investigate oxytocin receptor gene and high-risk women such as morbid obesity, preeclampsia and diabetes.

Our translational research program is an integral part of the Obstetric Anesthesia Program at the University of Toronto, which has comprehensive clinical research team. This will require coordination with a number of clinicians and nurses. Some projects will require extensive theoretical insight, interpretation of empirical data and the extraction of pertinent information from technical literature. The incumbent will assist with the modification of procedures, as well as designing or creating new procedures/ technical approaches as necessary based on experimental results.


  • Lead various laboratory research studies and participate in all activities of research including literature search, study conception, experimentation, data collection, analysis and manuscript writing.
  • Prepare grant applications, research budgets, study protocols, and Research Ethics Board applications.
  • Organize the laboratory and its day-to-day operations (order supplies, maintain budgets, and assist with the development of new standard operating procedures).
  • Screen patients for study eligibility and obtain informed consent to participate in the study. Procure tissue samples. Liaise with study investigators, labor floor nurses, obstetricians and anesthesiologists during the study and ensure smooth flow of study. Perform muscle/vascular contractility experiments as per the designed protocol.
  • Prepare various precisely-measured drug solutions, maintain adequate circuit checkups of the organ bath system and pay strict attention to sterilization, cleaning and maintenance, calibration and troubleshooting of laboratory instruments/ equipment.
  • Perform basic statistical analysis of the collected data. Organize and maintain research documents and database of all project activities within the group in a structured manner.
  • Participate and present our work in research seminars and conferences


  • The applicant should have strong expertise in physiology, pharmacology and laboratory genetics. Knowledge of molecular biology, cell culture and previous experience in myometrial or vascular models would be considered advantageous.
  • Must possess exceptional communication skills (verbal, written and presentation).
  • Must be versatile, self-motivated, with superior organizational and time management skills, professionalism, and dependability. Demonstrated knowledge of good clinical practice guidelines.
  • Demonstrated analytical and problem solving abilities with strong attention to detail. Knowledge of statistical softwares and database management will be an asset.
  • Excellent leadership skills. Ability to work with a variety of individuals in a co-operative manner, both independently and as part of a team.

The position is available immediately.

In accordance with Institute’s policy and legislated health and safety requirements, employment is conditional upon the verification of credentials, completion of a health review, and demonstrating proof of immunity and vaccination status of vaccine-preventable diseases. Successful candidates will be required to provide two (2) written reference letters from their former employer(s)/supervisor(s).

We are a fully committed to fairness and equity in employment and our recruitment and selection practices. We encourage applications from Indigenous peoples, people with disabilities, members of sexual minority groups, members of racialized groups, women and any others who may contribute to the further diversification of our Sinai Health community. Accommodation will be provided in all parts of the hiring process as required under our Access for People with Disabilities policy. Applicants need to make their requirements known in advance.

The Lunenfeld-Tanenbaum Research Institute is a scent sensitive environment and all members of the community are expected to refrain from wearing or using scented products while visiting or working at the Institute. We also support a barrier-free workplace supported by the Institute’s accessibility plan, accommodation and disability management policies and procedures. Should you require accommodation at any point during the recruitment process, including accessible job postings, please contact the Lunenfeld-Tanenbaum Human Resources Department.

Posting open until September 21, 2020. We thank all candidates for applying. Only those selected for an interview will be contacted.

Hours: 37.5 hours per week

Contact Name: Online
Contact Email: Online
Contact Phone: Online
Contact Fax: Online


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