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Sorry, the application deadline for this position was 4/15/2021

Reference Number: 000001445
Posted Date: 3/30/2021
Closing Date: 4/15/2021

Department: LTRI - CoVaRR-Net Program
Position: Research Associate

POSITION TITLE  Research Associate
EMPLOYMENT TYPE  Temporary Full Time
HOURS OF WORK  37.5 hours per week
REPORTS TO  Principal Investigator

The Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, a University of Toronto affiliated research centre, is one of the world's leading centres in biomedical research.  With ground-breaking discoveries in research areas such as diabetes, genetic disorders, cancer and women’s and infants’ health, the Institute is committed to excellence in health research and the training of young investigators.  Strong partnerships with the clinical programs of Mount Sinai Hospital ensure that scientific knowledge is used to promote human health.  Your significant contributions will assist in maintaining our momentum in advancing our research.


CoVaRR-Net relies on synergies and efficient communications across all pillars, with other members of the scientific community and with government bodies, to ensure a rapid response to the emergence of new SARS-CoV-2 Variants of Concerns (VOCs).

The mission of the “Functional Genomics and Structure-Function of VOCs Pillar” is to accelerate the functional and structural characterization of SARS-CoV-2 variants (i.e. protein mutants) through: a) the generation of synthetic sequences corresponding to each of the variants being tested; b) the transfer of these sequences into appropriate expression vectors for immediate sharing with the Canadian community; c) the purification of recombinant proteins (small scale) for testing variant function in vitro (e.g. binding to the host receptor), and d) the rapid dissemination of resources, protocols and knowledge to the scientific community.

The Molecular Biology and Biochemistry Specialist will have a key role in supporting the activities of the pillar, including, but not limited to:

  • design and synthesis of sequences corresponding to the prioritized variants and cloning them into entry vectors;
  • deposition of the constructs and maps in the CoVaRR-Net biobank, and in public resources available outside of Canada;
  • subcloning of the variants into relevant expression vectors as selected by the Pillar lead and co-leads;
  • production (small scale) of proteins in mammalian cells or other expression systems;
  • purification (small scale) of proteins for testing;
  • execution of binding assays and other biochemical and biophysical assays that can provide information on VOCs;
  • communication of all results to members of the pillar and external collaborators;
  • assisting with preparation of the results for publication or reports to government bodies.


  • Ph.D. in biochemistry, molecular genetics, molecular biology or a related speciality
  • Strong publication record
  • Demonstrated proficiency in molecular biology (recombinant DNA cloning, vector design, etc.)
  • Demonstrated proficiency in protein expression, protein purification (protein purification from mammalian cells is an asset)
  • Experience with other cell culture systems, immunological methods, and biochemical and biophysical methods is an asset
  • Competency in conducting literature reviews, research design, research methods, managing data, data analysis, knowledge translation
  • Must be able to exercise good judgment, exercise considerable independence, take initiative and possess  strong interpersonal skills
  • Must possess excellent communication skills (verbal, written and presentation) and be comfortable engaging and exchanging information with members of the network

Application Instructions

Apply through Interfolio (

1) Please include a cover letter outlining how you meet the qualifications for this position and why you would be an ideal candidate.

2) Provide a CV or biosketch.

3) Provide the name and contact information for three individuals that can provide a letter of recommendation on your behalf.

In accordance with Institute’s policy and legislated health and safety requirements, employment is conditional upon the verification of credentials, completion of a health review, and demonstrating proof of immunity and vaccination status of vaccine-preventable diseases.

We are a fully committed to fairness and equity in employment and our recruitment and selection practices. We encourage applications from Indigenous peoples, people with disabilities, members of sexual minority groups, members of racialized groups, women and any others who may contribute to the further diversification of our Sinai Health community. Accommodation will be provided in all parts of the hiring process as required under our Access for People with Disabilities policy. Applicants need to make their requirements known in advance.

The Lunenfeld-Tanenbaum Research Institute is a scent sensitive environment and all members of the community are expected to refrain from wearing or using scented products while visiting or working at the Institute. We also support a barrier-free workplace supported by the Institute’s accessibility plan, accommodation and disability management policies and procedures. Should you require accommodation at any point during the recruitment process, including accessible job postings, please contact the Lunenfeld-Tanenbaum Human Resources Department.

Posting open until April 15, 2021. We thank all candidates for applying. Only those selected for an interview will be contacted.

Hours: 37.5 hours per week

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