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Sorry, the application deadline for this position was 9/30/2022

Reference Number: 000001705
Posted Date: 8/2/2022
Closing Date: 9/30/2022

Department: Lunenfeld-Tanenbaum Research Institute
Position: Postdoctoral Fellow

POSITION TITLE  Postdoctoral Fellow
DEPARTMENT  Lunenfeld-Tanenbaum Research Institute
EMPLOYMENT TYPE  Temporary Full-Time  (two year contract with possibility of extension)
HOURS OF WORK  37.5 hours per week
REPORTS TO  Dr. Rod Bremner, Principal Investigator

The Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, a University of Toronto affiliated research centre, is one of the world's leading centres in biomedical research.  With ground-breaking discoveries in research areas such as diabetes, genetic disorders, cancer and women’s and infants’ health, the Institute is committed to excellence in health research and the training of young investigators.  Strong partnerships with the clinical programs of Mount Sinai Hospital ensure that scientific knowledge is used to promote human health.  Your significant contributions will assist in maintaining our momentum in advancing our research.



Applying Functional Genomics and a Simple Pan-Cancer Rule to Solve Drug Resistance Mechanisms in Highly Lethal Cancers



Drug resistance is a huge problem for cancer treatment, particularly that of highly lethal cancers such as acute myeloid leukemia (AML), small cell cancers (e.g., small cell lung cancer, SCLC; neuroendocrine prostate cancer, NEPC; and Glioblastoma, GBM).  Cancer heterogeneity and plasticity underlie drug resistance.  One challenging approach to this problem is to deduce all the mutations in all the cancer clones and treat each clone with the appropriate drug cocktail.  An alternative strategy is to identify overarching rules that govern cancer behavior, thus simplifying the disease into broad categories with the goal of exposing widely relevant therapeutic strategies.  In this vein, we discovered a simple code that parses all cancers into just two classes (Pearson et al Cancer Cell 2021, https://doi.org/10.1016/j.ccell.2021.06.016).  These classes are defined by the presence (YAPon) or absence (YAPoff) of the transcriptional coactivator YAP and its paralog TAZ as well as a set of YAP/TAZ target genes that govern adhesive behavior.  This binary code is functionally important because YAP/TAZ display opposite pro- or anti-cancer effects in YAPon and YAPoff cancers and these classes exhibit opposite adhesive properties. These contrasts are clinically relevant because the binary classes also display contrasting pharmaceutical and genetic vulnerabilities. Moreover, cancers switch binary classes to evade therapy.  With a focus on deadly cancers like AML, SCLC, PNEC, and GBM our goal is to exploit this new overarching rule to improve cancer therapeutics and block drug resistance.  For this, we are applying a suite of genomic and functional genomics tools in both human and murine models of cancer. We seek highly motivated and talented post docs with a strong background in informatics and genomics, who wish to build their own independent research career.  Please send your CV, a one-page summary of your research, and the phone number and email of two references to Dr. Bremner’s assistant: Simendeep Kaur skaur@lunenfeld.ca.


In accordance with Institute’s policy and legislated health and safety requirements, employment is conditional upon the verification of credentials, completion of a health review, and demonstrating proof of immunity and vaccination status of vaccine-preventable diseases. All employees and affiliates will follow safe work practices and comply with health and safety policies, procedures, and training. Successful candidates will be required to provide two (2) written reference letters from their former employer(s)/supervisor(s).

To ensure the safety and wellbeing of all our people and patients, Sinai Health has made it a priority to support everyone in getting vaccinated against COVID-19. Consistent with this, our Staff Immunization & Surveillance Policy was recently updated to include the requirement for full vaccination – currently defined as receiving two doses and serving a 14-day waiting period following the second dose – in order to be able to work at Sinai Health. To be compliant with our updated Policy, you must provide proof of dual COVID-19 vaccination, as indicated on the Prospective Immunization and Surveillance Policy Information Sheet, in order to be eligible for employment at Sinai Health. If you believe you are one of the very few people who may require an exemption from vaccination, supporting medical information must be submitted to our Occupational Health department, who will review and assess.

We are a fully committed to fairness and equity in employment and our recruitment and selection practices. We encourage applications from Indigenous peoples, people with disabilities, members of sexual minority groups, members of racialized groups, women and any others who may contribute to the further diversification of our Sinai Health community. Accommodation will be provided in all parts of the hiring process as required under our Access for People with Disabilities policy. Applicants need to make their requirements known in advance.

The Lunenfeld-Tanenbaum Research Institute is a scent sensitive environment, and all members of the community are expected to refrain from wearing or using scented products while visiting or working at the Institute. We also support a barrier-free workplace supported by the Institute’s accessibility plan, accommodation and disability management policies and procedures. Should you require accommodation at any point during the recruitment process, including accessible job postings, please contact the Lunenfeld-Tanenbaum Human Resources Department.



Posting open until September 30, 2022. We thank all candidates for applying. Only those selected for an interview will be contacted.

Hours: 37.5 hours per week

Contact Name: Online
Contact Email: Online
Contact Phone: Online


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