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Reference Number: 000001225
Posted Date: 7/30/2019
Closing Date: 8/30/2019

Department: Lunenfeld Tanenbaum Research Institute
Position: Research Associate in Mass Spectrometry and Chemical Proteomics

POSITION TITLE  Research Associate in Mass Spectrometry and Chemical Proteomics
DEPARTMENT  Lunenfeld Tanenbaum Research Institute
EMPLOYMENT TYPE  Regular Full-Time
HOURS OF WORK 37.5 hours per week
EMPLOYEE GROUP Non-Union
REPORTS TO Principal Investigar

POSITION OVERVIEW:

The Gingras lab at the Lunenfeld-Tanenbaum Research Institute is a world leader in developing and applying mass-spectrometry-based technologies to study protein interaction and function. A full-time research associate position is available to join this multi-disciplinary team to extend chemical proteomics capabilities in pre-clinical drug discovery and structural proteomics.  The successful applicant will develop and optimize new methodologies for drug target identification, protein complex composition and protein cross-linking for structural analysis by mass spectrometry.  The work will be in close cooperation with the established and well-equipped proteomics facility (nbcc.lunenfeld.ca/proteomics) and in the collaborative environment of the LTRI in the heart of the Discovery District in downtown Toronto.

DUTIES AND RESPONSIBILITIES:

The successful candidate will work as part of a team of proteomics experts, cellular biologists and biochemists to advance chemical and structural proteomics techniques in the Gingras laboratory.  S/he will design experiments and strategies to characterize lead molecule function and interaction with cellular proteins (in vivo and in vitro) and to define protein complex composition and structure. The research associate will design, plan and conduct experiments, develop or assist in developing computational workflows to analyze the data, and communicate the results in written or oral form. S/he will also help in drafting grant applications, progress reports, technical notes and scientific manuscripts. S/he will also train users in the new technologies that are being developed.

SKILLS/QUALIFICATIONS:

  • Ph.D. with 3 years experience (or M. Sc. with 6 years experience) in biological chemistry, biochemistry, organic chemistry, bioanalytical chemistry or any combination of equivalent experience and training

  • Strong publication record

  • Demonstrated proficiency in some or all of the following techniques: biochemistry (including protein purification and enzymatic assays, click-chemistry, cross-linking, dose-response), organic chemistry, and analytical chemistry

  • Experience in the development of target engagement and functional assays is required

  • Experience in biological mass spectrometry and quantitative proteomics is an asset

  • Experience with data analysis workflows using bioinformatics tools and packages (R, python) is an asset

  • Must be able to exercise good judgment, exercise considerable independence and take initiative

  • Demonstrated analytical and problem solving abilities with strong attention to detail

  • Must possess exceptional communication skills (verbal, written and presentation) and be comfortable engaging and exchanging information with other members of the laboratory and collaborators

  • Must demonstrate satisfactory work performance and attendance record

 

https://apply.interfolio.com/66200
 

 

Posting open until {August 30, 2019}. We thank all candidates for applying. Only those selected for an interview will be contacted.

Hours: 37.5 hours per week

Contact Name: Online

 

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