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Sorry, the application deadline for this position was 2/15/2020

Reference Number: 000001279
Posted Date: 12/13/2019
Closing Date: 2/15/2020

Department: Mass Spectrometry and Chemical Proteomics
Position: Research Associate

POSITION TITLE Research Associate
DEPARTMENT Mass Spectrometry and Chemical Proteomics
EMPLOYMENT TYPE Regular Full Time
HOURS OF WORK 37.5 hours per week
EMPLOYEE GROUP Non Union
REPORTS TO Principal Investigator

 POSITION OVERVIEW:

A position is available for a highly motivated Research Associate in Mass Spectrometry and Chemical Proteomics to join the laboratory of Anne-Claude Gingras at the Lunenfeld-Tanenbaum Research Institute (gingraslab.lunenfeld.ca).  Dr. Gingras, 2019 co-recipient of the HUPO Discovery in Proteomics Sciences Award, specializes in the study of protein complexes and subcellular proteome organization, combining innovative mass spectrometry-based approaches with modern cell and molecular biology techniques to accelerate discovery and gain deep biological insight into the mechanisms of disease. She has developed multiple experimental and computational approaches (many through collaborative efforts) to confidently identify and quantify interaction partners for proteins of interest, and has co-developed a number of widely used software tools to assist in this process. She has applied these powerful systematic approaches to a number of protein classes (e.g. phosphatases, bromodomain-containing proteins, RNA-binding proteins).

The Research Associate will join her multi-disciplinary team to build new chemical proteomics capabilities in pre-clinical drug discovery.  S/he will develop and optimize new methodologies for drug target identification and characterization, small molecule impact on protein complex composition and structure, and apply these approaches to the study of signaling molecules.

The Gingras lab is part of the Lunenfeld-Tanenbaum Research Institute’s Molecular, Cell and Systems Biology group (www.lunenfeld.ca/expertise) whose faculty members are internationally renowned for their work in signalling networks, cancer and developmental biology, structural biology, imaging, high- throughput screening and proteomics. The Institute provides a research-intensive environment with modern and cutting-edge core facilities that include robotics, proteomics and imaging that drive technology development (Network Biology Collaborative Centre, NBCC; nbcc.lunenfeld.ca). The Research Associate will work with colleagues in the proteomics group of the NBCC to develop and apply new approaches.  Lunenfeld-Tanenbaum Research Institute labs engage in productive collaborations within the Institute, Sinai Health System, the larger University of Toronto community, and beyond. The University of Toronto has one of the most concentrated biomedical research communities in the world, including 9 academic hospital research institutes that are fully affiliated with the University.

DUTIES AND RESPONSIBILITIES: 

The successful candidate will work as part of a team of proteomics experts, cellular biologists and biochemists to advance chemical proteomics techniques in the Gingras laboratory.  S/he will drive the chemoproteomics portfolio forward by designing experiments and strategies to characterize lead molecule function and its interaction with cellular proteins (in vivo and in vitro). The research associate will design, plan and conduct experiments, develop or assist in developing computational workflows to analyze the data, and communicate the results in written or oral form. S/he will also help in drafting grant applications, progress reports, technical notes and scientific manuscripts. S/he will also train users in the new technologies that are being developed. 

SKILLS/QUALIFICATIONS:

  • Ph.D. with 3 years experience (or M. Sc. with 6 years experience) in biological chemistry, biochemistry, organic chemistry, bioanalytical chemistry or any combination of equivalent experience and training
  • Strong publication record
  • Demonstrated proficiency in some or all of the following techniques: biochemistry (including protein purification and enzymatic assays, click-chemistry, cross-linking, dose-response), organic chemistry, and analytical chemistry
  • Experience in the development of assays to identify and characterize drug engagement with cellular targets is required
  • Experience in biological mass spectrometry and quantitative proteomics is preferred
  • Experience with data analysis workflows using bioinformatics tools and packages (R, python) is an asset
  • Must be able to exercise good judgment, exercise considerable independence and take initiative
  • Demonstrated analytical and problem solving abilities with strong attention to detail
  • Must possess exceptional communication skills (verbal, written and presentation) and be comfortable engaging and exchanging information with other members of the laboratory and collaborators
  • Must demonstrate satisfactory work performance and attendance record

Please include a cover letter outlining how you meet the qualifications for this position and why you would be an ideal candidate.

 

Posting open until February 15, 2020. We thank all candidates for applying. Only those selected for an interview will be contacted.

Hours: 37.5 hours of work

Contact Name: Online
Contact Email: Online
Contact Phone: Online
Contact Fax: Online

 

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