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OPPORTUNITIESINSTRUCTIONS

Reference Number: 000001594
Posted Date: 1/14/2022
Closing Date: 4/8/2022

Department: LTRI/ RTC
Position: Postdoctoral Fellow

POSITION TITLE  Postdoctoral Fellow
DEPARTMENT  LTRI / RTC
EMPLOYMENT TYPE  Full Time
HOURS OF WORK  37.5 hours per week
EMPLOYEE GROUP  Non Union
REPORTS TO  Principal Investigator

POSITION OVERVIEW:

The Laboratory of Dr. Daniel Schramek is a newly established research group in the Department of Molecular, Cell and Systems Biology at the Lunenfeld-Tanenbaum Research Institute. We are looking for highly motivated, well-organized, and hard-working postdoctoral fellows, who want to contribute to cutting-edge biomedical research with a focus on functional genomics, disease modeling in mice, cancer, tumor immunology and epigenetics. If you are a caring and ambitious junior scientist interested in learning new skills and willing to develop an independent research program within a highly dynamic and ambitious research environment, we encourage you to apply.

The Lab: https://schramek.lunenfeld.ca

The Schramek Lab combines large-scale direct in vivo CRISPR screens with various mouse models of cancer to integrate human cancer genomics for rapid discovery and functional characterization of putative cancer driver mutations and novel drug targets. Using ultrasound-guided in utero injection of lentiviral sgRNAs to selectively transduce various organs of living mouse embryos in a mosaic fashion, Dr. Schramek has developed a methodology to rapidly assess hundreds of genes in a single mouse.  We first focused on Head & Neck Squamous Cell Carcinomas, the 6th most common cancer worldwide with a mortality of >50%, and identified several novel tumor suppressors involved in the initiation and the metastatic progression of this horrible disease. (Schramek et al., Science 2014 and Loganathan et al, Science 2020).

Now, the lab will leverage this unique lentiviral gene function analysis to systematically analyze putative cancer genes not only in Head & Neck cancer but also in gliomas, pancreas, breast and lung cancer. We will also start to screen for specific cancer vulnerabilities and for ways to improve current cancer therapies or for ways to avoid the emergence of resistance mechanisms with the aim to advance personalized medicine

Experience in  cancer biology or mouse genetics is desirable but not essential.

The Principal Investigator

Daniel Schramek is a cancer biologist and investigator at the Lunenfeld-Tanenbaum Research Institute since 2015. He is also Assistant Professor at the University of Toronto's Department for Molecular Genetics. He has a track record in establishing and studying various mouse models of cancer and has developed several forward and reverse genetic screening methodologies to uncover novel disease-related genes. He received a BSc and MSc in Molecular Biology with high distinction from the University of Vienna and University of Sydney and a PhD in Genetics with high distinction from the University of Vienna and the Austrian Academy of Sciences (supervisor Prof. Josef Penninger, Best PhD Award). Dr. Schramek competed his postdoctoral training in the Laboratory of Prof. Elaine Fuchs at the Rockefeller University and also graduated from the Polytechnic School of Engineering, New York University (NYU), with an Executive MSc in Technology Management with high distinction.

Dr. Schramek advanced the field of functional genomics by developing several breakthrough technologies such as the first genome- wide RNAi screens in Drosophila, specialized 3D cell culture models, haploid ES cell screening and established rapid RNAi-based screening in mice generating non-germline, genetically engineered mouse models.

REQUIRED QUALIFICATIONS:

 

PhD. in Molecular Genetics, Cellular Biology, Biochemistry or related field required

 

Next generation sequencing: Experience in preparing samples for genome, epigenome, and transcriptome mapping desired

 

• Experience with mouse models of human diseases desired

• Experience with mouse models of brain cancer desired

• Familiarity with molecular genetic techniques

• Strong organizational skills

 Strong communication skills including verbal, written and electronic

• Ability to maintain a high level of accuracy

• Ability to work independently and to develop a new research direction

• Able to function well within a team setting

• Self-directed, highly motivated and results driven

 

Please submit your cover letter and resume directly to schramek@lunenfeld.ca. We thank all candidates for applying. This is a highly competitive competition and those selected for an interview will be contacted shortly.

In accordance with Institute’s policy and legislated health and safety requirements, employment is conditional upon the verification of credentials, completion of a health review, and demonstrating proof of immunity and vaccination status of vaccine-preventable diseases.

The Lunenfeld-Tanenbaum Research Institute is a scent sensitive environment and all members of the community are expected to refrain from wearing or using scented products while visiting or working at the Institute. We also support a barrier-free workplace supported by the Institute’s accessibility plan, accommodation and disability management policies and procedures. Should you require accommodation at any point during the recruitment process, including

Accessible job postings, please contact the Lunenfeld-Tanenbaum Human Resources Department.

Contact Name: Dr. Daniel Schramek

 

In accordance with Institute’s policy and legislated health and safety requirements, employment is conditional upon the verification of credentials, completion of a health review, and demonstrating proof of immunity and vaccination status of vaccine-preventable diseases. All employees and affiliates will follow safe work practices and comply with health and safety policies, procedures, and training. Successful candidates will be required to provide two (2) written reference letters from their former employer(s)/supervisor(s).

To ensure the safety and wellbeing of all our people and patients, Sinai Health has made it a priority to support everyone in getting vaccinated against COVID-19. Consistent with this, our Staff Immunization & Surveillance Policy was recently updated to include the requirement for full vaccination – currently defined as receiving two doses and serving a 14-day waiting period following the second dose – in order to be able to work at Sinai Health. To be compliant with our updated Policy, you must provide proof of dual COVID-19 vaccination, as indicated on the Prospective Immunization and Surveillance Policy Information Sheet, in order to be eligible for employment at Sinai Health. If you believe you are one of the very few people who may require an exemption from vaccination, supporting medical information must be submitted to our Occupational Health department, who will review and assess.

We are a fully committed to fairness and equity in employment and our recruitment and selection practices. We encourage applications from Indigenous peoples, people with disabilities, members of sexual minority groups, members of racialized groups, women and any others who may contribute to the further diversification of our Sinai Health community. Accommodation will be provided in all parts of the hiring process as required under our Access for People with Disabilities policy. Applicants need to make their requirements known in advance.

The Lunenfeld-Tanenbaum Research Institute is a scent sensitive environment, and all members of the community are expected to refrain from wearing or using scented products while visiting or working at the Institute. We also support a barrier-free workplace supported by the Institute’s accessibility plan, accommodation and disability management policies and procedures. Should you require accommodation at any point during the recruitment process, including accessible job postings, please contact the Lunenfeld-Tanenbaum Human Resources Department.

 

 

Posting open until April 8, 2022. We thank all candidates for applying. Only those selected for an interview will be contacted.

Hours: 37.5 hours per week

Contact Name: Online
Contact Email: Online
Contact Phone: Online
Contact Fax: Online

 

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