_menu_for_cvbank | Lunenfeld-Tanenbaum HR

Lunenfeld-Tanenbaum Research Institute

Research Resources  |   RTC  |   sciHigh  |   HR & CV Bank  |   Finance  |   Grants  |   Technology Transfer  |   Administrative Assistants  |   Biobar  |   Safety  |  
● Job Applicants   ● LTRI Employers  
 Lunenfeld-Tanenbaum Human Resources 

Sorry, the application deadline for this position was 1/19/2024

Reference Number: 000001908
Posted Date: 12/7/2023
Closing Date: 1/19/2024

Department: LTRI
Position: Postdoctoral Fellow, Molecular Neuroscience

POSITION TITLE  Postdoctoral Fellow, Molecular Neuroscience
EMPLOYMENT TYPE  Temporary, Full-Time
HOURS OF WORK  37.5 hours per week
REPORTS TO  Principal Investigator


The Tsukahara lab (https://www.tsukaharalab.org, https://www.lunenfeld.ca/?page=tsukahara-tatsuya) at the Lunenfeld-Tanenbaum Research Institute (LTRI) is looking for an enthusiastic postdoctoral fellow to work on the molecular mechanisms through which neurons encode their experience in forms of gene and protein expression and optimize functions.



The LTRI of Sinai Health System, a University of Toronto affiliated research centre, is one of the world's leading centres in biomedical research.  With ground-breaking discoveries in research areas such as diabetes, genetic disorders, cancer and women’s and infants’ health, the Institute is committed to excellence in health research and the training of young investigators.  Strong partnerships with the clinical programs of Sinai Health System ensure that scientific knowledge is used to promote human health.  Your significant contributions will assist in maintaining our momentum in advancing our research.

In addition, Toronto has a strong neuroscience community across multiple institutions including the LTRI, SickKids Research Institute, and Krembil Brain Institute. The lab has access to stellar core facilities for sequencing, proteomics, imaging, flow cytometry, and metabolomics. The LTRI also has one of the best academic mouse facilities in North America.


Position Overview:

We have an open position for a postdoctoral fellow working molecular mechanisms through which neurons convert the history of neural activity and neuromodulatory signals that signify internal states or life stages into functional changes through gene and protein expression. Our lab primarily uses the olfactory system, especially peripheral sensory neurons in the nose, as an in vivo model. By applying cutting edge technologies including single-cell and spatial genomics and proteomics, our lab aims to characterize:

  1. how social odors are represented by the peripheral sensory neurons.
  2. epigenetic regulation of activity-dependent gene expression.
  3. activity-dependent changes in proteomes.
  4. how signals that signify internal states (hunger, stress, inflammation) or life stages (puberty, sexual experience, pregnancy, lactation, aging, etc) affect gene expression and sensory responses.

We are also interested in how sensory responses and transcriptional adaptation are affected in autism model mice as deficits in social behavior and sensory adaptation (which leads to sensory hypersensitivity) are associated with autism.


Other potential future projects include:

  1. exploring the link between social behavior and genome (especially chemoreceptor sequence) and sensory coding by comparing mouse inbred strains including wild-derived CAST mice.
  2. establishing an in vitro neuronal culture system in which we can optogenetically manipulate neural activity in an analog fashion and quantify corresponding changes in physiological properties and gene/protein expression within the same individual neurons.
  3. characterize transcriptional mechanisms of plasticity in other systems (sensory, learning and memory).

It is possible to conceive projects that are not described above through discussion.


Education and skills:


  • A doctoral degree in biology related research field (by the start date).
  • Strong expertise in molecular biology and/or computational data analysis (Python, R).
  • Strong communication skills through experience of working within a scientific research team and collaboration.
  • Ability to think about the projects critically and independently.


  • Experience in genome-wide approach including chromatin profiling, single-cell biology, and spatial transcriptomics.
  • Experience in animal research.


How to Apply:

Please apply to the job posting at the link above attaching:

  1. A cover letter explaining expertise and the candidate’s interests to this position
  2. Curriculum Vitae including education and publication list
  3. Contact information of three references


For positions in a laboratory environment, Lunenfeld-Tanenbaum Research Institute’s Safety Requirements include:

  • Maintain personal certifications as required by Safety Office
  • Maintain the lab’s Safety requirements as required by Safety Office
  • Maintain current lab-specific Standard Operating Procedures (SOPs) - including work with hazardous chemicals and biological agents, hazardous waste disposal, etc.
  • Maintain the lab’s chemical Inventory
  • Responsible for training the lab members on lab-specific procedures, weekly eye wash checks

In accordance with Institute’s policy and legislated health and safety requirements, employment is conditional upon the verification of credentials, completion of a health review, and demonstrating proof of immunity and vaccination status of vaccine-preventable diseases. All employees and affiliates will follow safe work practices and comply with health and safety policies, procedures, and training. Successful candidates will be required to provide two (2) written reference letters from their former employer(s)/supervisor(s).

To ensure the safety and wellbeing of all our people and patients, Sinai Health has made it a priority to support everyone in getting vaccinated against COVID-19. Consistent with this, our Staff Immunization & Surveillance Policy was recently updated to include the requirement for full vaccination – currently defined as receiving two doses and serving a 14-day waiting period following the second dose – in order to be able to work at Sinai Health. To be compliant with our updated Policy, you must provide proof of dual COVID-19 vaccination, as indicated on the Prospective Immunization and Surveillance Policy Information Sheet, in order to be eligible for employment at Sinai Health. If you believe you are one of the very few people who may require an exemption from vaccination, supporting medical information must be submitted to our Occupational Health department, who will review and assess.

We are a fully committed to fairness and equity in employment and our recruitment and selection practices. We encourage applications from Indigenous peoples, people with disabilities, members of sexual minority groups, members of racialized groups, women and any others who may contribute to the further diversification of our Sinai Health community. Accommodation will be provided in all parts of the hiring process as required under our Access for People with Disabilities policy. Applicants need to make their requirements known in advance.

The Lunenfeld-Tanenbaum Research Institute is a scent sensitive environment, and all members of the community are expected to refrain from wearing or using scented products while visiting or working at the Institute. We also support a barrier-free workplace supported by the Institute’s accessibility plan, accommodation and disability management policies and procedures. Should you require accommodation at any point during the recruitment process, including accessible job postings, please contact the Lunenfeld-Tanenbaum Human Resources Department.



Posting open until January 19, 2024. We thank all candidates for applying. Only those selected for an interview will be contacted.

Hours: 37.5 hours per week

Contact Name: Online
Contact Email: Online
Contact Phone: Online


Returning Applicants?

Just a reminder — this Website requires that you sign-in to fill out application forms and to upload files. The sign-in link is located in the top-right corner of this page.

New Applicants?

If you are new to this Website and do not have an ID, the sign-in script will allow you to create one — just click the sign-in link located in the top-right corner of this page and follow the on-screen instructions; or click the link here directly to create a User ID.