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Reference Number: 000001937
Posted Date: 4/3/2024
Closing Date: 5/20/2024

Department: LTRI, Sinai Health
Position: Postdoctoral Fellow in Fetal Brain Protection

POSITION TITLE Postdoctoral Fellow
HOURS OF WORK 37.5 hours per week
REPORTS TO Principal Investigator ( Dr. Stephen Matthews) 


Applications are invited for a postdoctoral fellow position at the Lunenfeld-Tanenbaum Research Institute, Sinai Health, to participate in our CIHR-funded program in Fetal Brain Protection. The preterm human infant is vulnerable to neurotoxicity due to immaturity of the blood-brain barrier. The developing brain has intrinsic protective transporter systems that can prevent transfer of xenobiotics into the brain. However, little is known as to how these transporters are regulated during the fetal and perinatal period. Our program is focused towards increasing knowledge in this critical area and to identify strategies to improve fetal and neonatal brain health.

The successful candidate will undertake studies to investigate the function and regulation of drug transporter systems in the developing blood-brain barrier. These will include primarily cell-based approaches in human cells but may also include in vivo experiments in animal models. Advanced blood-brain barrier modelling will be utilized along with cellular and molecular approaches, including imaging, transcriptomic and epigenetic analysis. Particular emphasis will be placed on the interaction of cell-types within the neurovascular unit in the regulation of blood-brain barrier function.

One postdoctoral fellowship is immediately available to join Professor Matthews’ Lab. The successful candidate will develop research based on well-delineated hypotheses to generate novel experimental data. The position will initially be for one year with the possibility of a one-year renewal.


This fellowship is suitable for candidates who have a Ph.D. in molecular, cellular, or developmental biology, biochemistry, physiology, pharmacology or relevant fields. Significant experience with in vitro cell culture, protein and mRNA quantification, transcriptomics, proteomics, epigenetics and bioinformatics will be a major asset. Excellent writing and presentation skills are also required.


The Lunenfeld-Tanenbaum Research Institute (LTRI) of Sinai Health System is one of the Canada’s leading biomedical research institutes. At LTRI, the Women’s and Infant’s Health Research group comprises multi-disciplinary scientists specialized in research in reproductive health sciences.

How to Apply:

Please submit a cover letter, curriculum vitae, and contact information of three references to the following Interfolio site http://apply.interfolio.com/144012

Application deadline is May 20th 2024.

We thank all those expressed interests. Only candidates who are shortlisted will be contacted.

In accordance with Institute’s policy and legislated health and safety requirements, employment is conditional upon the verification of credentials, completion of a health review, and demonstrating proof of immunity and vaccination status of vaccine-preventable diseases. All employees and affiliates will follow safe work practices and comply with health and safety policies, procedures, and training. Successful candidates will be required to provide three (3) written reference letters from their former employer(s)/supervisor(s).

To ensure the safety and wellbeing of all our people and patients, Sinai Health has made it a priority to support everyone in getting vaccinated against COVID-19. Consistent with this, our Staff Immunization & Surveillance Policy was recently updated to include the requirement for full vaccination – currently defined as receiving two doses and serving a 14-day waiting period following the second dose – in order to be able to work at Sinai Health. To be compliant with our updated Policy, you must provide proof of dual COVID-19 vaccination, as indicated on the Prospective Immunization and Surveillance Policy Information Sheet, in order to be eligible for employment at Sinai Health. If you believe you are one of the very few people who may require an exemption from vaccination, supporting medical information must be submitted to our Occupational Health department, who will review and assess.

We are a fully committed to fairness and equity in employment and our recruitment and selection practices. We encourage applications from Indigenous peoples, people with disabilities, members of sexual minority groups, members of racialized groups, women and any others who may contribute to the further diversification of our Sinai Health community. Accommodation will be provided in all parts of the hiring process as required under our Access for People with Disabilities policy. Applicants need to make their requirements known in advance.

The Lunenfeld-Tanenbaum Research Institute is a scent sensitive environment, and all members of the community are expected to refrain from wearing or using scented products while visiting or working at the Institute. We also support a barrier-free workplace supported by the Institute’s accessibility plan, accommodation and disability management policies and procedures. Should you require accommodation at any point during the recruitment process, including accessible job postings, please contact the Lunenfeld-Tanenbaum Human Resources Department.



Posting open until May 20, 2024. We thank all candidates for applying. Only those selected for an interview will be contacted.

Hours: 37.5 hours per week

Contact Name: Online
Contact Email: https://apply.interfolio.com/144012
... applications accepted via external service.
Contact Phone: Online
Contact Fax: Online


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